Expert:

Prof Julia Scarisbrick

Institution:

University Hospital Birmingham, UK

Speciality:

Dermatology

Therapeutic Areas of interest:

ECP in Dermatologic Diseases

Expertise:

Co-author of the European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis, 2020
Author of The PROCLIPI international registry, an important tool to evaluate the prognosis of cutaneous T cell lymphomas, 2022
Co-author of The Role of Extracorporeal Photopheresis in the management of Cutaneous T – Cell Lymphoma, Graft versus Host Disease and Organ Transplant Rejection: A consensus statement update from the UK Photopheresis Society, 2017
Expert in the usage of ECP for CTCL (evidence, guidelines, and novel tools to measure response)

Bio:

Prof Scarisbrick is Consultant Dermatologist at the University Hospital Birmingham and leads the Cutaneous Lymphoma Service
She holds an Honorary Chair at the University of Birmingham in the Institute of Immunology and Immunotherapy
Her research interest is focused on both clinical and molecular research fields for cutaneous lymphoma, she has a successful translational research program, and is involved in the development and delivery of both academic and commercial clinical studies
She is Past Chairperson of the EORTC Cutaneous Lymphoma Group, European Director for Cutaneous Lymphoma International Consortium, Trustee and Past Chairperson for the UK Photopheresis Society, Secretary and Chair Elect for the International Society of Cutaneous Lymphoma and Trustee for the UK Cutaneous Lymphoma Group (Past Chair).
She is involved in the development of clinical guidelines in cutaneous lymphoma, and ECP
In 2015 she was the Chairperson UK Expert of the Photopheresis Group coordinating research projects and developing guidelines (Former chairperson of the group btw 2015 – 2022)

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IMPORTANT SAFETY INFORMATION FOR THE THERAKOS™ PHOTOPHERESIS PROCEDURE

Indications

The THERAKOS^TM CELLEX^TM Photopheresis System is indicated for the administration of photopheresis. Please refer to the appropriate product labelling for a complete list of warnings and precautions.

Contraindications

THERAKOS^TM Photopheresis is contraindicated in:

Patients possessing a specific history of a light sensitive disease.
Patients who cannot tolerate extracorporeal volume loss or who have white blood cell counts greater than 25,000 / mm³.
Patients who have coagulation disorders or who have previously had a splenectomy.

Warnings and Precautions

THERAKOS^TM Photopheresis treatments should always be performed in locations where standard medical emergency equipment is available. Volume replacement fluids and/or volume expanders should be readily available throughout the procedure. Safety in children has not been established.

Do not expose the device to a magnetic resonance (MR) environment. The device may present a risk of projectile injury, and thermal injury and burns may occur. The device may generate artifacts in the MR image, or may not function properly.
Thromboembolic events, including pulmonary embolism and deep vein thrombosis, have been reported in the treatment of Graft versus Host Disease (GvHD). Special attention to adequate anticoagulation is advised when treating patients with GvHD.
When prescribing and administering THERAKOS^TM Photopheresis for patients receiving concomitant therapy, exercise caution when changing treatment schedules to avoid increased disease activity that may be caused by abrupt withdrawal of previous therapy.

Adverse Events

Hypotension may occur during any treatment involving extracorporeal circulation. Closely monitor the patient during the entire treatment for hypotension.
Transient pyretic reactions, 37.7–38.9°C (100–102°F), have been observed in some patients within six to eight hours of reinfusion of the photoactivated leukocyte-enriched blood. A temporary increase in erythroderma may accompany the pyretic reaction.
Treatment frequency exceeding labelling recommendations may result in anaemia.
Venous access carries a small risk of infection and pain.

Please refer to the THERAKOS^TM CELLEX^TM Photopheresis System Operator Manual for a complete list of warnings and precautions.

IMPORTANT SAFETY INFORMATION FOR METHOXSALEN USED IN CONJUNCTION WITH THERAKOS^TM PHOTOPHERESIS

Contraindications

Methoxsalen is contraindicated in:

Patients exhibiting idiosyncratic or hypersensitivity reactions to methoxsalen, psoralen compounds, or any of the excipients
Patients with co-existing melanoma, basal cell or squamous cell skin carcinoma
Patients who are pregnant, and sexually active men and women of childbearing potential unless adequate contraception is used during treatment
Patients with aphakia because of the significantly increased risk of retinal damage due to the absence of a lens

Warnings and Precautions

Special care should be exercised in treating patients who are receiving concomitant therapy (either topically or systemically) with known photosensitizing agents.
Oral administration of methoxsalen followed by cutaneous UVA exposure (PUVA therapy) is carcinogenic.
Patients should be told emphatically to wear UVA absorbing, wrap-around sunglasses for twenty-four (24) hours after methoxsalen treatment. They should wear these glasses any time they are exposed to direct or indirect sunlight, whether they are outdoors or exposed through a window.
Safety in children has not been established.

Refer to the package insert for methoxsalen sterile solution (20 micrograms / mL) or the oral 8-methoxypsoralen dosage formulation for a list of all warnings and precautions.

Please refer to the THERAKOS^TM CELLEX^TMPhotopheresis System Operator Manual for a complete list of warnings, precautions and adverse events.

Expert:

Prof Julia Scarisbrick

Expertise:

Bio:

Request to book a session with Prof Julia Scarisbrick

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IMPORTANT SAFETY INFORMATION FOR THE THERAKOS™ PHOTOPHERESIS PROCEDURE

IMPORTANT SAFETY INFORMATION FOR METHOXSALEN USED IN CONJUNCTION WITH THERAKOSTM PHOTOPHERESIS

IMPORTANT SAFETY INFORMATION FOR METHOXSALEN USED IN CONJUNCTION WITH THERAKOS^TM PHOTOPHERESIS