Educational Course on Lung Transplant Rejection

The Goal

The goal of the lung transplant rejection interactive course is to provide the latest trends and expert views on the treatment of lung BOS with GvHD and foster discussion between peers.

Agenda

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Day 1 - 21 May 2024

Arrival of participants

20:00 – 20:15
Meeting at hotel lobby

20:15
Dinner with the faculty

Day 2 - 22 May 2024

09:00 – 09:10
Welcome and course goals introduction - Prof Peter Jaksch

09:10 – 09:55
Extracorporeal photopheresis in lung transplantation ‘how did we get there?’ a historic perspective from Zürich - Prof Christian Benden

09:55 – 10:10
Interactive discussion

10:10 – 10:30
Coffee break

10:30 – 11:15
Patient selection under times of changing definitions – the Hannover approach; Patient selection and treatment algorithm - Dr Mark Greer

11:15 – 11:30
Interactive discussion

11:30 – 12:15
Vienna experiences and future directions - Prof Peter Jaksch

12:15 – 12:30
Interactive discussion

12:30 – 13:30
Lunch

13:30 – 14:30
Patient cases discussion- All

14:30 – 15:00
Final remarks and close - Prof Peter Jaksch

BOS: Bronchiolitis obliterans syndrome, GvHD: Graft versus Host Disease, ECP: Extracorporeal Photopheresis

For this course, participants are required to submit one patient case for discussion 15 days in advance of the session.

All speakers are subject to contract.
This is a commercial programme run by Therakos (UK) Ltd, part of Mallinckrodt Pharmaceuticals
This information is not intended for healthcare professionals based in the US and Canada.

Hosted by

Prof Peter Jaksch

Head of Lung Transplant Unit, Vienna Medical Hospital, Vienna, Austria

Brought to you by the Therakos Institute

This is a commercial programme run by Therakos (UK) Ltd, part of Mallinckrodt Pharmaceuticals

IMPORTANT SAFETY INFORMATION FOR THE THERAKOS™ PHOTOPHERESIS PROCEDURE

Indications

The THERAKOS™ CELLEX™ Photopheresis System is indicated for patients older than 18 years of age for the administration of photopheresis in the following:

Cutaneous T Cell Lymphoma (CTCL)
Solid Organ Transplant Rejection (SOT) (heart, lung)

The THERAKOS™ CELLEX™ Photopheresis System is indicated in patients older than 3 years of age for the management of:

Acute and Chronic Graft versus Host Disease (aGvHD, cGvHD)

Contraindications

THERAKOS^TM Photopheresis is contraindicated in:

Patients possessing a specific history of a light sensitive disease
Patients who cannot tolerate extracorporeal volume loss or who have white blood cell counts greater than 25,000 / mm³
Patients who have coagulation disorders or who have previously had a splenectomy

Warnings and Precautions

THERAKOS^TMPhotopheresis treatments should always be performed in locations where standard medical emergency equipment is available. Volume replacement fluids and/or volume expanders should be readily available throughout the procedure.

Do not expose the device to a magnetic resonance (MR) environment. The device may present a risk of projectile injury, and thermal injury and burns may occur. The device may generate artifacts in the MR image, or may not function properly.
Thromboembolic events, including pulmonary embolism and deep vein thrombosis, have been reported in the treatment of Graft versus Host Disease (GvHD). Special attention to adequate anticoagulation is advised when treating patients with GvHD.
When prescribing and administering THERAKOS Photopheresis for patients receiving concomitant therapy, exercise caution when changing treatment schedules to avoid increased disease activity that may be caused by abrupt withdrawal of previous therapy.

Adverse Events

Hypotension may occur during any treatment involving extracorporeal circulation. Closely monitor the patient during the entire treatment for hypotension.
Transient pyretic reactions, 37.7–38.9°C (100–102°F), have been observed in some patients within six to eight hours of reinfusion of the photoactivated leukocyte-enriched blood. A temporary increase in erythroderma may accompany the pyretic reaction.
Treatment frequency exceeding labelling recommendations may result in anaemia.
Venous access carries a small risk of infection and pain.

IMPORTANT SAFETY INFORMATION FOR METHOXSALEN USED IN CONJUNCTION WITH THERAKOS^TM PHOTOPHERESIS

Consult the 8-methoxypsoralen (Methoxsalen (20 micrograms / mL)) professional leaflet or the oral 8-methoxypsoralen formulation package insert before prescribing or dispensing any medication.